Nanogen NanoGuard B Original Formula

Introduction to Nanoguard B active

Before you can understand how Nanoguard-B works, it is important to know about the hair follicle's life cycle. Each hair goes through this cycle independently of all other hairs on the scalp:

In addition to a twice-weekly shampoo Nanoguard A, which has patented anti-DHT properties, new Nanoguard-B is a once-daily aqueous solution applied directly to the scalp with three additional properties clinically proven to increase hair density and reduce hairloss:

Regulates the hormonal balance

Hair follicles in the cases of androgenetic alopecia show an abnormally high level of DHT, an androgen converted from testosterone by the enzyme 5a-reductase. By inhibiting 5a-reductase activity, Nanoguard b severely limits the transformation of T into DHT, thereby limiting the cause of androgenetic alopecia.

Nanoguard B active tested at 0.25% on human fibroblasts shows a significant inhibiting effect on 5 Alpha-reductase II activity (-18%). This effect is comparable with a reference compound, finasteride.
By inhibiting the activity of this enzyme, the Nanoguard B active limits the transformation of testosterone in 5 Alpha-DHT which is responsible for the follicles miniaturization characteristic of androgenetic alopecia.

Improves vascularization of the hair follicle

Formation of the vascular system near the follicle is an important and necessary factor in the development of hair. VEGF (vascular-endothelial growth factor) is one essential growth factor & has been shown to stimulate both neovascularization, also known as angiogenesis (new blood vessel growth) and vascular permeability (the capacity of a blood vessel wall to pass through small molecules, like water or nutrients).

Photograph depicting Nanoguard B (1%) active effect on angiogenesis.

Nanoguard B increases VEGF by over 30%, as well as making the existing vascular system around the hair follicle denser, which is necessary to provide follicles in the Anagen phase with the nutrients required for hair growth.

Nanoguard B active tested at 0.25%, 0.5% and 1% increases formation of vessels from the existing system. Nanoguard B active favours angiogenesis and thus facilitates the supply of oxygen and nutrients that are essential for cells during the anagen phase, during which cellular activity is very intense.

Stimulates cell metabolism

Cells in the Anagen phase are dividing continuously to support the formation and growth of hair. Therefore the metabolic activity of the cells around the hair follicle needs to be at a maximum for the formation of healthy hair growth. Nanoguard b provides zinc, iron and growth peptides to stimulate and boost metabolic activity in the hair bulb cells, favouring the growth of hair.

Nanoguard active (1%) favours the expression of mRNA coding for type 1 transglutaminase, a marker of keratinocyte differentiation. By boosting the metabolic activity of cells, an important process in the anagen phase, Nanoguard B stimulates hair growth.